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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

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Published on: December 6, 2016

Obstructive sleep apnea is a risk factor for osteoarthritis.

Asiye Kanbay¹, Oğuz Köktürk², Aylin Pıhtılı³

¹Department of Chest Diseases, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Tuberkuloz Ve Toraks

|January 27, 2019

Summary

Severe obstructive sleep apnea (OSA) is strongly linked to severe osteoarthritis (OA). This study found a significant association between OSA severity and OA grade, suggesting OSA may be a novel risk factor for OA development.

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Area of Science:

Orthopedics
Sleep Medicine
Cardiology

Background:

Obstructive sleep apnea (OSA) is linked to cardiovascular and metabolic disorders.
Osteoarthritis (OA) is associated with cardiovascular disease and inflammation, a metabolic disorder.
Metabolic disorders connect OA and OSA, prompting investigation into their relationship.

Purpose of the Study:

To investigate the association between obstructive sleep apnea severity and osteoarthritis grade.
To explore if OSA is a risk factor for OA development.

Main Methods:

A cross-sectional study recruited patients suspected of OSA undergoing polysomnography.
Patients were categorized by apnea-hypopnea index (AHI) into mild, moderate, severe OSA, and control groups.
Osteoarthritis severity was graded using the Kellgren-Lawrence scoring system (0-4).

Main Results:

A strong correlation was found between OSA severity and OA grade.
All patients (33) with Grade 4 OA had severe OSA; none with Grade 1 OA had severe OSA (p<0.05).
This association was independent of body-mass index and correlated positively with hs-CRP levels.

Conclusions:

A strong association exists between obstructive sleep apnea and osteoarthritis.
OSA may represent a novel risk factor for osteoarthritis development.
Further research is recommended to assess the impact of OSA treatment on OA.