Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Families02:47

Protein Families

16.8K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
16.8K
Protein Families02:47

Protein Families

4.4K
4.4K
Gene Families01:57

Gene Families

9.9K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
9.9K
Gene Families01:57

Gene Families

3.8K
3.8K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

53.5K
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
53.5K
Rab Cascades01:25

Rab Cascades

3.6K
Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary Cutaneous Rosai-Dorfman Disease Presenting as an Infiltrative Dorsal Nasal Mass With Deep Skeletal Muscle Involvement.

The American Journal of dermatopathology·2026
Same author

Severe hypertriglyceridemia due to heterozygous LPL variant, ApoE ε2ε2 genotype, and environmental interactions in an 11-year-old boy.

Journal of clinical lipidology·2026
Same author

Dapsone-Induced Systemic Drug Reaction in a Patient With Immunoglobulin A Vasculitis.

Cureus·2026
Same author

Interdigitating Dendritic Cell Sarcoma Arising on the Skin: An Exceedingly Rare Tumor With a Poor Prognosis.

The American Journal of dermatopathology·2026
Same author

Metabolic syndrome in youth - A fresh look at an old problem.

Journal of clinical lipidology·2025
Same author

Sebelipase Alfa Improves Aminotransferase Levels in Lysosomal Acid Lipase Deficiency: Data From an International Registry.

Liver international : official journal of the International Association for the Study of the Liver·2025
Same journal

Parental childhood vaccination hesitancy and refusal in Türkiye: A systematic review of contributing factors.

Journal of pediatric nursing·2026
Same journal

The effect of sticker intervention on children's pain and anxiety after invasive procedures.

Journal of pediatric nursing·2026
Same journal

Addressing Pediatric COVID-19 Vaccine Hesitancy through Community Engagement: A Descriptive Evaluation of the VaxUpPhillyFamilies program.

Journal of pediatric nursing·2026
Same journal

Associations between healthy lifestyle belief among adolescents their sociodemographic characteristics and parental healthy life education conscious level.

Journal of pediatric nursing·2026
Same journal

A clinical pathway for young adults with medical complexity in a pediatric emergency department.

Journal of pediatric nursing·2026
Same journal

The effect of psychological resilience on caregiver burden among parents of children with special needs: The mediating role of internalized stigma.

Journal of pediatric nursing·2026
See all related articles

Related Experiment Video

Updated: Jan 30, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

8.5K

Reverse Cascade Screening for Familial Hypercholesterolemia.

Amelia Vinson1, Lisa Guerra1, Luke Hamilton1

  • 1Pediatric Endocrinology and Diabetes, Cook Children's Medical Center, Fort Worth, TX, USA.

Journal of Pediatric Nursing
|January 27, 2019
PubMed
Summary
This summary is machine-generated.

Early cholesterol screening in youth with familial hypercholesterolemia (FH) identifies affected families, reducing future cardiovascular disease (CVD) risk. Pediatric nurses are key in this reverse cascade screening (RCS) process.

Keywords:
ChildrenCholesterolFamilial hypercholesterolemiaReverse cascade screening

More Related Videos

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

18.4K
Examining BCL-2 Family Function with Large Unilamellar Vesicles
08:35

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Published on: October 5, 2012

8.4K

Related Experiment Videos

Last Updated: Jan 30, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
10:56

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes

Published on: September 15, 2018

8.5K
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

18.4K
Examining BCL-2 Family Function with Large Unilamellar Vesicles
08:35

Examining BCL-2 Family Function with Large Unilamellar Vesicles

Published on: October 5, 2012

8.4K

Area of Science:

  • Cardiovascular Health
  • Genetics
  • Pediatric Medicine

Background:

  • Cardiovascular disease (CVD) is a leading cause of death, with elevated atherogenic cholesterol as a major contributor.
  • Familial hypercholesterolemia (FH) significantly increases the risk of premature CVD.
  • Cholesterol screening in youth offers a unique opportunity for early identification and intervention.

Purpose of the Study:

  • To review the literature on cholesterol screening in youth and familial hypercholesterolemia (FH).
  • To outline the role of pediatric nurses in lipid clinics and reverse cascade screening (RCS).
  • To discuss the effectiveness, barriers, and implications of RCS for youth with FH.

Main Methods:

  • A comprehensive PubMed literature review was conducted.
  • The review focused on articles published between 2000 and 2016.
  • Keywords included familial hypercholesterolemia and cholesterol screening of youth.

Main Results:

  • Cholesterol screening in youth is effective in identifying individuals with FH.
  • Pediatric nurses play a crucial role in education, care coordination, and family screening.
  • Potential barriers to RCS include cost and confidentiality concerns.

Conclusions:

  • Early identification and intervention for youth with FH can significantly reduce future CVD events.
  • RCS is a powerful tool for identifying affected family members, potentially detecting all cases.
  • Ethical, psychological, and financial implications of RCS programs must be carefully considered.