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Barrier-free patterned paper sensors for multiplexed heavy metal detection
Liming Zhang1, Liyun Guan2, Zhuoxuan Lu1
1Key Laboratory of Tropical Diseases and Translational Medicine of the Ministry of Education & Hainan Provincial Key Laboratory of Tropical Medicine, Hainan Medical College, Haikou 571199, China.
Talanta
|January 27, 2019
Summary
Researchers developed a novel, simple method for creating patterned paper sensors without hydrophobic barriers. This barrier-free approach enables direct signal readout for detecting heavy metals like iron, nickel, and copper.
Area of Science:
- Analytical Chemistry
- Materials Science
- Biomedical Engineering
Background:
- Paper-based analytical devices (PADs) offer potential for information embedding and data interpretation.
- Fabrication of patterned PADs is crucial for their application but often requires complex methods.
- The physical properties of paper substrates significantly influence assay performance.
Purpose of the Study:
- To propose a simple and effective barrier-free paper patterning method.
- To investigate the influence of paper structure on precipitation and non-precipitation assays.
- To demonstrate the fabrication of patterned paper sensors for heavy metal detection.
Main Methods:
- Investigated the effect of paper physical properties on Fe(II) detection assays.
- Developed a barrier-free patterning approach without hydrophobic boundaries.
- Fabricated patterned paper sensors on low-bulk and medium-thick paper substrates.
Main Results:
- Demonstrated direct patterned signal readout on paper substrates without hydrophobic barriers.
- Achieved low detection limits for heavy metals: 0.25 ppm for Fe(II), 0.4 ppm for Ni(II), and 0.5 ppm for Cu(II).
- Successfully fabricated barrier-free patterned paper sensors for heavy metal detection.
Conclusions:
- Barrier-free paper patterning is a viable and promising approach for fabricating PADs.
- Paper structure plays a key role in the performance of precipitation and non-precipitation assays.
- This method simplifies the fabrication of patterned paper sensors, enhancing their potential applications.
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