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Nanocurcumin improves regulatory T-cell frequency and function in patients with multiple sclerosis
Sanam Dolati1, Zohreh Babaloo2, Hormoz Ayromlou3
1Immunology Research Center, Tabriz University of Medical Sciences Tabriz, Iran; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Student's Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Nanocurcumin treatment increased regulatory T cells (Treg) frequency and function in patients with relapsing-remitting multiple sclerosis (RRMS). This suggests nanocurcumin may help restore immune balance in MS patients.
Area of Science:
- Immunology
- Neuroscience
- Pharmacology
Background:
- Multiple sclerosis (MS) is a chronic central nervous system disease.
- Disturbances in regulatory T cell (Treg) subpopulations are linked to disability in relapsing-remitting MS (RRMS).
Purpose of the Study:
- To investigate the effects of nanocurcumin on Treg cell frequency and function in RRMS patients.
Main Methods:
- 50 RRMS patients were randomized into nanocurcumin or placebo groups for six months.
- Blood samples were analyzed for Treg cell frequency, transcription factor expression (FoxP3), and cytokine secretion (TGF-β, IL-10) using flow cytometry, real-time PCR, and ELISA.
Main Results:
- Nanocurcumin treatment significantly increased Treg cell frequency and expression of FoxP3, TGF-β, and IL-10 compared to placebo.
- Secretion levels of TGF-β and IL-10 were also elevated in the nanocurcumin group.
Conclusions:
- Nanocurcumin effectively restores Treg cell frequency and function in patients with MS.
- These findings highlight nanocurcumin's potential therapeutic role in managing MS.
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