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Correlation between the DEPDC5 rs1012068 polymorphism and the risk of HBV-related hepatocellular carcinoma

Wenxuan Liu1, Ning Ma1, Dongqiang Zhao2

  • 1Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human health, Shi Jiazhuang, PR China.

Clinics and Research in Hepatology and Gastroenterology
|January 27, 2019
PubMed

Insights

Hepatocellular carcinoma (HCC) risk is linked to a common genetic variant, DEPDC5 rs1012068, in the Han Chinese population. The A to C mutation in DEPDC5 increases the likelihood of developing Hepatitis B virus (HBV)-related HCC.

Area of Science:

  • Genetics
  • Hepatology
  • Cancer Research

Background:

  • Hepatocellular carcinoma (HCC) is primarily caused by Hepatitis B virus (HBV) or Hepatitis C virus (HCV) infection.
  • The precise molecular mechanisms by which HBV contributes to HCC development remain unclear.
  • A 2011 genome-wide association study (GWAS) identified a DEPDC5 gene variant associated with HCC susceptibility in HCV-infected patients.

Purpose of the Study:

  • To investigate the association between DEPDC5 gene polymorphism and HBV-related HCC.
  • To determine if DEPDC5 rs1012068 variants influence HCC risk in the Han Chinese population.

Main Methods:

  • A cohort of 1289 individuals from northern China was studied, including healthy controls, patients with chronic Hepatitis B (CHB), liver cirrhosis (LC), and HBV-related HCC.
  • Single nucleotide polymorphisms (SNPs) in DEPDC5 rs1012068 were genotyped using MALDI-TOF-MS.
  • Statistical analyses controlled for factors such as sex, smoking, and alcohol consumption.

Main Results:

  • A significant correlation was found between DEPDC5 rs1012068 polymorphism and HBV-related HCC.
  • Individuals with the CC genotype had a 2.008-fold increased risk of HCC compared to controls.
  • The CC genotype was also associated with increased risk in CHB (2.241-fold) and LC (2.706-fold) patients.
  • The AC genotype showed a 1.615-fold increased risk of HCC.

Conclusions:

  • The DEPDC5 rs1012068 A/C polymorphism is significantly associated with HBV-related HCC in the Han Chinese population.
  • The A to C mutation within DEPDC5 rs1012068 appears to elevate the risk of developing HBV-related HCC.
Abstract

Keywords:
DEPDC5Hepatitis B virusHepatocellular carcinomaPolymorphisms

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