Inhibiting neuraminidase can make the difference
Rino Rappuoli1,2, Giuseppe Del Giudice3
1GlaxoSmithKline, Siena, Italy rino.r.rappuoli@gsk.com.
Abstract:
Immunogens inducing antibodies against the stem of influenza virus hemagglutinin are promising candidates for the development of universal vaccines. In this issue of JEM, Kosik et al. (https://doi.org/10.1084/jem.20181624) report that inhibition of neuraminidase by anti-stem antibodies contributes to their broadly neutralizing activity.
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