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Updated: Jan 30, 2026

Detection of Lung Tumor Progression in Mice by Ultrasound Imaging
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Retraction Note: Hsa-miR-623 suppresses tumor progression in human lung adenocarcinoma

Shuang Wei1, Zun-Yi Zhang2, Sheng-Ling Fu2

  • 1Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Key Cite of National Clinical Research Center for Respiratory Disease, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, China.

Cell Death & Disease
|January 27, 2019
PubMed

Insights

This study on lung adenocarcinoma progression is retracted due to A549 cell line contamination with Hela cells. The experimental findings are unreliable, impacting conclusions on tumor growth.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Lung adenocarcinoma is a major cause of cancer mortality.
  • MicroRNAs play crucial roles in cancer development and progression.
  • Specific microRNAs are investigated for their potential as therapeutic targets.

Purpose of the Study:

  • To investigate the role of Hsa-miR-623 in the progression of human lung adenocarcinoma.
  • To determine the impact of Hsa-miR-623 on tumor growth and metastasis.
  • To evaluate Hsa-miR-623 as a potential therapeutic target for lung adenocarcinoma.

Main Methods:

  • Utilized human lung adenocarcinoma cell lines (A549).
  • Performed experiments involving manipulation of Hsa-miR-623 expression.
  • Assessed tumor progression markers and cell behavior.

Main Results:

  • The study initially reported that Hsa-miR-623 suppresses tumor progression in lung adenocarcinoma.
  • Observed effects on cell proliferation, migration, and invasion.

Conclusions:

  • The article has been retracted due to contamination of A549 cells with Hela cells.
  • The contamination may have influenced the experimental outcomes.
  • The conclusions drawn from this study are considered unreliable.

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