Related Experiment Video

Updated: Jan 30, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.7K

Comparison of neutropenia profiles in different treatment protocols for acute myeloid leukemia using the D-index

Yasufumi Kawasaki1, Shun-Ichi Kimura2, Hirofumi Nakano1

  • 1Division of Hematology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

International Journal of Hematology
|January 27, 2019
PubMed

Insights

This study compared neutropenia profiles in acute myeloid leukemia (AML) patients receiving different chemotherapy regimens. Regimens impact neutropenia depth and duration, necessitating tailored infection management strategies.

Area of Science:

  • Oncology
  • Hematology
  • Pharmacology

Background:

  • Neutropenia is a significant risk factor for opportunistic infections in acute myeloid leukemia (AML) patients undergoing chemotherapy.
  • Understanding neutropenia profiles associated with different chemotherapy regimens is crucial for managing infectious complications.

Purpose of the Study:

  • To retrospectively compare the D-index, reflecting neutropenia depth and duration, between two distinct chemotherapy regimens for AML.
  • To analyze how daunorubicin (DNR) versus idarubicin (IDR) induction, followed by standard-dose cytarabine (SDAC) versus high-dose cytarabine (HDAC) consolidation, affects neutropenia profiles.

Main Methods:

  • Retrospective comparison of the D-index in 67 AML patients.
  • Patients received either DNR + cytarabine induction followed by SDAC consolidation or IDR + cytarabine induction followed by high-dose cytarabine (HDAC) consolidation.

Main Results:

  • The idarubicin (IDR) regimen resulted in a shorter duration of neutropenia but a higher D-index compared to the daunorubicin (DNR) regimen.
  • The D-index during consolidation therapy was significantly higher with standard-dose cytarabine (SDAC) compared to high-dose cytarabine (HDAC).

Conclusions:

  • Neutropenia profiles vary significantly between different AML chemotherapy regimens.
  • Physicians must tailor the management of infectious complications based on the specific neutropenia profile associated with each treatment regimen.
Keywords:
Acute myeloid leukemiaAnthracyclineD-indexHigh-dose cytarabineNeutropenia

More Related Videos

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

30.5K
Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice10:02

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

Published on: January 6, 2023

2.5K

Related Concept Videos

Drug Dissolution: Requirements and Profile Comparison01:14

Drug Dissolution: Requirements and Profile Comparison

The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
269
The Sense of Self: Reflected Self-Appraisal and Social Comparison02:57

The Sense of Self: Reflected Self-Appraisal and Social Comparison

According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
56.0K
Multiple Comparison Tests01:13

Multiple Comparison Tests

Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
4.5K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.0K
Comparison Between Electrical And Gravitational Forces01:24

Comparison Between Electrical And Gravitational Forces

There are four fundamental forces in nature: the gravitational force, the electromagnetic force, the strong nuclear force, and the weak nuclear force. To compare the numerical strengths of the first two, take two particles of the same kind. Since electrons are fundamental particles, they are a good example.
Since both are inverse square law forces, the distance gets canceled when the ratio of the two forces is considered. Instead, the ratio of the electrical and gravitational forces depends on...
4.0K
Comparison between RL and RC circuits01:24

Comparison between RL and RC circuits

An RC circuit consists of resistance and capacitance, while in an RL circuit, capacitance is replaced by an inductor. RL and RC circuits are first-order differential circuits that store energy. An RC circuit stores energy in the electric field, while an RL circuit stores energy in the magnetic field. When connected to a battery, an RC circuit charges the capacitor, causing the current to decrease from maximum to zero upon being fully charged. This increases the voltage across the capacitor from...
6.1K