Nitric oxide and hydrogen sulfide - markers of acute period of polytrauma

Introduction: Polytrauma or multiple organ damage is connected with shock and organ failure, which in severely injured patients and if untreated quick can lead to death.). The aim: To investigate levels of NO, NOx and H2S in patients with acute trauma period at the time of hospitalization and for 24 hours after trauma.

Materials and method: Etiology of trauma: traffic accident - 78 %, drop from the altitude - 5 %, everyday trauma - 17 %. Blood tests were performed during patient admission and 24 hours after admission.

Results: Results of the study in patients with severe polytrauma showed increase of serum NO and its metabolites, but decrease of H2S. Suggest increase of NОx is connected with severity of trauma and can be as indicator of prognosis for severity of injury in polytrauma. So detection of NO and its metabolites and H2S can be use as early markers of detection for severity of polytrauma.

Conclusions: Intensive care management in acute polytrauma period leads to increase of NO level and its metabolites on the background of H2S decrease. Detection of NO, NOx, H2S and valuation of its balance in acute period of polytrauma can serve as severity indicators and prognosis of these disease. In comparation to general clinical parameters, gasotrasmitters react on changes in homeostasis faster and more sensitive what allows to use them more widely as biomarkers of organ disfunction development in acute polytrauma period.