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Related Experiment Video

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Bioluminescent Orthotopic Model of Pancreatic Cancer Progression
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Meningioma Surgery-Are We Making Progress?

Torstein R Meling1, Michele Da Broi2, David Scheie3

  • 1Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Neurosurgery, Oslo University Hospital, Oslo, Norway; Department of Neurosurgery, Geneva University Medical Center, Geneva, Switzerland; Faculty of Medicine, University of Geneva, Geneva, Switzerland.

World Neurosurgery
|January 27, 2019
PubMed
Summary
This summary is machine-generated.

Outcomes for intracranial meningioma surgery have improved, with higher rates of complete tumor removal and better patient survival over two decades. This study shows advancements in surgical techniques and patient care lead to better long-term results.

Keywords:
ComplicationsCraniotomyImprovementIntracranial tumorMeningiomaOverall survivalRetreatment-free survival

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Area of Science:

  • Neurosurgery
  • Oncology
  • Medical Outcomes Research

Background:

  • Intracranial meningiomas represent a significant proportion of primary brain tumors.
  • Surgical management of meningiomas has evolved over recent decades.
  • Assessing long-term outcomes is crucial for understanding treatment efficacy.

Purpose of the Study:

  • To evaluate trends and improvements in surgical outcomes for intracranial meningiomas.
  • To analyze changes in patient demographics and surgical results over time.
  • To identify factors contributing to enhanced patient survival and reduced complications.

Main Methods:

  • A longitudinal observational study design was employed.
  • 1469 patients undergoing intracranial meningioma surgery were analyzed across four distinct time periods (1990-2010).
  • Statistical analyses, including odds ratios and multivariate analysis, were used to compare outcomes.

Main Results:

  • Later surgical periods showed a trend toward operating on older patients.
  • Gross total resection rates (Simpson grade I-II) improved significantly after the year 2000.
  • Perioperative mortality and worsened neurologic outcomes decreased significantly in later decades.
  • Retreatment-free survival and overall survival showed significant increases over the study period.

Conclusions:

  • Surgical management and patient populations for intracranial meningiomas have evolved.
  • Increased rates of gross total resection correlate with improved perioperative and long-term outcomes.
  • Advancements in surgical care have led to better overall survival and retreatment-free survival for meningioma patients.