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Published on: March 15, 2014
Correcting aberrant kinetochore microtubule attachments: a hidden regulation of Aurora B on microtubules
1Laboratory of Chromosome and Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Abstract:
For equal chromosome segregation, a pair of kinetochores on each duplicated chromosome must attach to microtubules connecting to opposite poles. The protein kinase Aurora B plays a critical role in destabilizing microtubules attached in a wrong orientation through phosphorylating kinetochore proteins. The mechanism behind this selective destabilization of aberrant attachments remains elusive. While Aurora B is most enriched on the centromere from prophase to metaphase, emerging evidence suggests the importance of Aurora B on microtubules in this process. Here I discuss two hypothetical models that could explain the requirement of Aurora B on microtubules for selective destabilization of aberrant attachments; microtubule-induced substrate masking and treadmill-removal of Aurora B on microtubules proximal to polymerizing ends.
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