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Published on: July 22, 2020
Changes in lipids composition and metabolism in colorectal cancer: a review
Alicja Pakiet1,2, Jarosław Kobiela3, Piotr Stepnowski1
1Department of Environmental Analysis, Faculty of Chemistry, University of Gdansk, Gdansk, Poland.
Abstract:
Altered metabolism of lipids is currently considered a hallmark characteristic of many malignancies, including colorectal cancer (CRC). Lipids are a large group of metabolites that differ in terms of their fatty acid composition. This review summarizes recent evidence, documenting many alterations in the content and composition of fatty acids, polar lipids, oxylipins and triacylglycerols in CRC patients' sera, tumor tissues and adipose tissue. Some of altered lipid molecules may be potential biomarkers of CRC risk, development and progression. Owing to a significant role of many lipids in cancer cell metabolism, some of lipid metabolism pathways may also constitute specific targets for anti-CRC therapy.
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