Related Experiment Video
Updated: Jan 30, 2026

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
Published on: December 3, 2016
Freiberg Disease and Avascular Necrosis of the Metatarsal Heads
1Boulder Centre for Orthopedics, 4740 Pearl Parkway, Boulder, CO 80301, USA.
Abstract:
Freiberg disease is characterized as osteochondrosis of the second metatarsal head. It is the fourth most common form of primary osteochondrosis with a significant predilection to the adolescent athletic female population, although it has been seen over a wide age range. If treated early, osteochondroses such as Freiberg disease are essentially self-limiting, often resolving with nonoperative management. When surgery is warranted, it is imperative the patient's age, activity level, and degree of articular deformity be taken into account.
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