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[T-cell-antigen positive, E-rosette negative acute lymphoblastic leukaemia (author's transl)]
Blut
|June 20, 1978
Summary
T cell antigen expression in acute lymphocytic leukaemia (ALL) lymphoblasts was studied. T antigen can classify undifferentiated leukaemias, and E-T+ ALL indicates a poor prognosis in children.
Area of Science:
- Immunology
- Hematology
- Oncology
Context:
- Investigated lymphoblasts from 100 acute lymphocytic leukaemia (ALL) patients.
- Examined expression of sheep erythrocyte receptors (E) and T cell antigen (T).
Purpose:
- To characterize T cell markers in ALL lymphoblasts.
- To determine the diagnostic and prognostic significance of T cell antigens in ALL.
Summary:
- 17/100 cases showed both E and T cell markers (E+T+).
- 13/100 cases showed only T cell markers (E-T+).
- E-T+ lymphoblasts exhibited T antigen expression comparable to or higher than normal T lymphocytes.
- Acid phosphatase and complement receptors were also assessed.
- T antigen proved useful in classifying undifferentiated and unclassifiable leukaemias.
- E-T+ ALL in children correlated with a poor prognosis, with 5/9 deaths soon after diagnosis.
Impact:
- T cell antigen expression is a valuable marker for classifying ALL subtypes.
- Identification of E-T+ ALL aids in risk stratification and prognosis.
- This research contributes to understanding T cell differentiation in leukaemic cells.