Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Free radicals in aging.

D Harman1

  • 1Department of Medicine, University of Nebraska College of Medicine, Omaha 68105.

Molecular and Cellular Biochemistry
|December 1, 1988
PubMed
Summary
This summary is machine-generated.

Aging, the accumulation of cellular damage, may be caused by free radical reactions. Modifying diet and antioxidant intake could extend healthy lifespan by 5-10 years, potentially mitigating age-related diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Operational Definition of Active and Healthy Ageing (AHA): A Conceptual Framework.

The journal of nutrition, health & aging·2015
Same author

Antioxidant supplements: Effects on disease and aging in the United States population.

Journal of the American Aging Association·2013
Same author

Alzheimer's disease: A hypothesis on pathogenesis.

Journal of the American Aging Association·2013
Same author

Myctolaimellus robiniae n. sp. (Diplogasterida: Cylindrocorporidae) from Larval Cavities of the Locust Borer, Megacyllene robiniae Forster.

Journal of nematology·2009
Same author

Aging: overview.

Annals of the New York Academy of Sciences·2002
Same author

Development of muscarinic analgesics derived from epibatidine: role of the M4 receptor subtype.

The Journal of pharmacology and experimental therapeutics·1999
Same journal

Correction to: Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein.

Molecular and cellular biochemistry·2026
Same journal

Galectin-3, transforming growth factor beta 1, and brain natriuretic peptide in cardiac remodeling under hyperlipidemic and hyperglycemic stress.

Molecular and cellular biochemistry·2026
Same journal

Ellagic acid from the traditional Chinese medicinal herb Scutellaria barbata may accelerates apoptosis in hepatic stellate cells during liver fibrosis via inhibiting miR-182-5p.

Molecular and cellular biochemistry·2026
Same journal

GeneQuantify: a web-based tool for qPCR gene expression and copy number variation analysis.

Molecular and cellular biochemistry·2026
Same journal

NCAPG reprograms glycolytic and lipid metabolism by sustaining glycerophospholipid flux in small-cell lung cancer.

Molecular and cellular biochemistry·2026
Same journal

Combination of sitagliptin and mangiferin mitigates testicular damage induced by paclitaxel via mediating Sestrin2/Keap1/Nrf2 signaling pathway.

Molecular and cellular biochemistry·2026
See all related articles

Area of Science:

  • Gerontology and molecular biology
  • Investigating the biological mechanisms of aging

Background:

  • Aging is a primary cause of death, characterized by progressive, irreversible changes.
  • The free radical theory of aging proposes that accumulated damage from free radicals drives this process.
  • This theory is supported by evolutionary, radiation, dietary, and disease-pathogenesis studies.

Purpose of the Study:

  • To explore the role of free radical reactions in the aging process.
  • To examine the link between free radical reactions and age-related diseases.
  • To assess the potential of dietary and antioxidant interventions to extend healthy lifespan.

Main Methods:

  • Review of existing scientific literature on aging and free radical reactions.
  • Analysis of studies on life span, radiation effects, and disease pathogenesis.

Related Experiment Videos

  • Evaluation of dietary interventions and antioxidant supplementation effects on aging.

    • Main Results:

    • Evidence supports free radical reactions as a significant contributor to aging.
    • Genetic and environmental factors modulate free radical damage, leading to diseases like cancer and atherosclerosis.
    • Dietary modifications and antioxidants show potential for increasing healthy active lifespan.

    Conclusions:

    • Free radical reactions are a plausible mechanism underlying the aging process.
    • Interventions targeting free radical damage, such as diet and antioxidants, may extend healthy lifespan.
    • Understanding free radical pathology is crucial for combating age-related diseases.