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Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are...
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Manufacturing chimeric antigen receptor T cells: issues and challenges.

Claire Roddie1, Maeve O'Reilly1, Juliana Dias Alves Pinto2

  • 1Research Department of Haematology, University College London, London, UK; Department of Haematology, University College London Hospitals National Health Service (NHS) Foundation Trust, London.

Cytotherapy
|January 28, 2019
PubMed
Summary

Chimeric antigen receptor (CAR) T-cell therapy shows promise for B-cell malignancies. This review explores manufacturing and quality control methods to meet rising clinical demand for CAR T-cells.

Keywords:
CliniMACS Prodigychimeric antigen receptor T cellsimmunotherapylentiviral vectors

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Area of Science:

  • Immunotherapy
  • Oncology
  • Cellular Therapy

Background:

  • Adoptive transfer of CD19 chimeric antigen receptor (CAR) T cells yields significant responses in relapsed refractory B-cell malignancies.
  • FDA approval of two CAR T-cell products highlights therapeutic advancements for high-risk patients.

Purpose of the Study:

  • To review current and novel CAR T-cell processing methodologies.
  • To discuss essential quality control systems for CAR T-cell manufacturing.

Main Methods:

  • Literature review of CAR T-cell processing techniques.
  • Analysis of quality control strategies in cellular therapy manufacturing.

Main Results:

  • CAR T-cell therapy has demonstrated unprecedented efficacy in clinical trials.
  • Increasing demand necessitates scalable and reproducible manufacturing processes.

Conclusions:

  • Efficient and standardized manufacturing processes are crucial for meeting the growing clinical need for CAR T-cell therapies.
  • Robust quality control systems are vital to ensure the consistent delivery of high-quality CAR T-cell products.