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Related Concept Videos

ATP Driven Pumps III: V-type Pumps01:30

ATP Driven Pumps III: V-type Pumps

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V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
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ATP Driven Pumps II: P-type Pumps01:34

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The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
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Pumped Concrete01:13

Pumped Concrete

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Concrete in large quantities can be pumped across long distances for placing in inaccessible sites. This system comprises a hopper that receives concrete from a mixer, a pump to propel the concrete, and pipelines that facilitate its delivery.
For direct-acting pumps, the concrete enters the pump via the inlet valve under the action of gravity and suction created by the movement of the piston. This concrete is then forced into the pipeline and out through the outlet valve by the forward movement...
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Refrigerators and Heat Pumps01:07

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Refrigerators or heat pumps are heat engines operating in a reverse direction. For a refrigerator, the focus is on removing heat from a specific area, whereas, for a heat pump, the focus is on dumping heat into one particular area. A refrigerator (or heat pump) absorbs heat Qc from the cold reservoir at Kelvin temperature Tc and discards heat Qh to the hot reservoir at Kelvin temperature Th, while work W is done on the engine’s working substance.
A household refrigerator removes heat from...
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Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
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ATP Driven Pumps I: An Overview01:27

ATP Driven Pumps I: An Overview

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ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and...
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Implantation of Miniosmotic Pumps and Delivery of Tract Tracers to Study Brain Reorganization in Pathophysiological Conditions
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MIDCAB versus off-pump CABG: Comparative study.

Yunbin Xu1, Yong Li1, Weiguo Bao1

  • 1Department of Cardiovascular Surgery, The Second Hospital of Shandong University, Jinan 250033, PR China.

Hellenic Journal of Cardiology : HJC = Hellenike Kardiologike Epitheorese
|January 28, 2019
PubMed
Summary
This summary is machine-generated.

Minimally invasive direct coronary artery bypass (MIDCAB) offers better outcomes than traditional off-pump coronary artery bypass (OPCAB). MIDCAB demonstrates improved efficacy and safety with reduced trauma, making it a recommended procedure.

Keywords:
Coronary artery bypass graftCoronary heart diseaseInternal mammary arteryOff-pump

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Area of Science:

  • Cardiovascular Surgery
  • Minimally Invasive Procedures

Background:

  • Coronary artery bypass grafting is a common treatment for coronary artery disease.
  • Traditional median sternotomy approaches carry significant morbidity.
  • Minimally invasive techniques aim to reduce surgical trauma and improve patient recovery.

Purpose of the Study:

  • To evaluate the clinical significance and mid-term outcomes of minimally invasive direct coronary artery bypass (MIDCAB).
  • To compare MIDCAB with traditional off-pump coronary artery bypass (OPCAB) via median sternotomy.

Main Methods:

  • Retrospective analysis of 300 patients undergoing off-pump coronary artery bypass.
  • Patients were divided into MIDCAB (n=90) and OPCAB (n=210) groups.
  • Comparison of preoperative, perioperative, and 7-year follow-up data.

Main Results:

  • MIDCAB group had fewer distal anastomotic stomas, shorter operation time, less blood transfusion, and reduced postoperative support needs (ventilator, ICU, hospital stay).
  • MIDCAB patients showed higher left ventricular ejection fraction (LVEF) and vessel patency rates at 7-year follow-up.
  • OPCAB group had higher age and more vascular lesions, with lower LVEF compared to MIDCAB.

Conclusions:

  • MIDCAB is a safe and effective alternative to median sternotomy OPCAB.
  • MIDCAB offers advantages of small incision, minimal trauma, and positive mid-term clinical outcomes.
  • The procedure is recommended for promotion due to its demonstrated benefits.