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RAGE Signaling in Skeletal Biology
Lilian I Plotkin1,2,3, Alyson L Essex4,5, Hannah M Davis4,5
1Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Dr., MS 5023, Indianapolis, IN, 46202, USA. lplotkin@iupui.edu.
Current Osteoporosis Reports
|January 28, 2019
Summary
The receptor for advanced glycation end products (RAGE) and its ligands impact bone health, influencing homeostasis and disease. Understanding RAGE signaling in bone cells is key to targeting bone diseases.
Area of Science:
- Skeletal Biology
- Cellular Signaling
- Pathophysiology
Background:
- The receptor for advanced glycation end products (RAGE) and its ligands are involved in aging, inflammation, and cellular stress.
- Their specific role in bone homeostasis and disease remains incompletely understood.
- RAGE signaling's cell-type specific effects in bone cells are largely unknown.
Purpose of the Study:
- To review the literature on RAGE signaling in skeletal biology.
- To discuss the potential of RAGE as a diagnostic and therapeutic target for bone diseases.
Main Methods:
- Literature review of RAGE signaling in skeletal biology.
- Analysis of RAGE and ligand roles in bone cell function and disease.
Main Results:
- RAGE ligands like AGEs and HMGB1 have dual effects on osteoblasts, with low levels promoting function and high levels causing apoptosis.
- Elevated RAGE ligands induce osteoblast/osteocyte apoptosis and cytokine production, increasing osteoclast activity.
- RAGE signaling is crucial for skeletal development, homeostasis, and repair, but its dysregulation is linked to bone loss and fragility.
Conclusions:
- RAGE and its ligands play a significant physiological role in bone health.
- Dysregulated RAGE signaling contributes to bone diseases characterized by loss and fragility.
- Further research is needed to fully elucidate RAGE's complex role in skeletal biology and its therapeutic potential.
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