Long-term adherence to ambulatory initiated continuous positive airway pressure in non-syndromic OSA children

Related Experiment Video

Updated: Jan 30, 2026

Laryngeal Mask Airway LMA Placement in a Neonatal Patient Simulator Using a Non-Inflatable Supraglottic Airway SGA
04:56

Laryngeal Mask Airway LMA Placement in a Neonatal Patient Simulator Using a Non-Inflatable Supraglottic Airway SGA

Published on: July 14, 2023

5.0K

M-P Perriol1, I Jullian-Desayes2,3, M Joyeux-Faure4,5

  • 1Unité Veille-Sommeil, Hôpital Jean Bernard, Valenciennes, France.

Sleep & Breathing = Schlaf & Atmung
|January 28, 2019
PubMed

Insights

Continuous positive airway pressure (CPAP) adherence in children with obstructive sleep apnea (OSA) remained high over two years, supporting ambulatory initiation. This suggests potential benefits for neurocognition and metabolic health.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Respiratory Care

Background:

  • Obstructive Sleep Apnea (OSA) in children often requires Continuous Positive Airway Pressure (CPAP) therapy, particularly for residual cases post-surgery or obesity-related persistent OSA.
  • Data on long-term adherence to ambulatory CPAP initiation in pediatric populations are limited.

Purpose of the Study:

  • To evaluate the adherence rates (hours/night) of Continuous Positive Airway Pressure (CPAP) therapy in children over a 24-month period following ambulatory initiation.
  • To assess factors influencing CPAP adherence in a pediatric cohort with sleep-disordered breathing (SDB).

Main Methods:

  • An observational cohort study followed 78 children diagnosed with sleep-disordered breathing (SDB) symptoms and prescribed CPAP.
  • Polysomnography was used for diagnosis, and CPAP was initiated in a hospital setting for a subset of patients.
  • Adherence was monitored over 24 months, with data collected at 3, 6, 12, and 24 months.

Main Results:

  • Mean CPAP adherence was consistently high, ranging from 6.1 to 7.0 hours/night over the 24-month follow-up period.
  • A significant proportion of children remained on CPAP therapy throughout the study, with discontinuation often linked to successful rehabilitation, orthopedics, or weight loss.
  • Trends suggested higher adherence in younger children, those attending primary school, with higher baseline apnea-hypopnea indices, and those with neurocognitive disorders.

Conclusions:

  • Pediatric CPAP adherence, when initiated in an ambulatory setting, is high and sustained over two years.
  • These findings support the feasibility and effectiveness of ambulatory CPAP initiation for non-syndromic pediatric OSA.
  • Sustained high CPAP adherence is anticipated to correlate with improved neurocognitive, metabolic, and cardiovascular outcomes in children.
Abstract

Keywords:
AmbulatoryCPAP adherenceChildrenOSA

More Related Videos

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

23.9K
Ambulatory ECG Recording in Mice08:00

Ambulatory ECG Recording in Mice

Published on: May 27, 2010

24.8K

Related Concept Videos

Initiation of Translation02:33

Initiation of Translation

Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
39.0K
Initiation of Translation02:33

Initiation of Translation

8.1K
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
Transcription Initiation01:47

Transcription Initiation

Initiation is the first step of transcription in eukaryotes. Prokaryotic RNA Polymerase (RNAP) can bind to the template DNA and start transcribing. On the other hand, transcription in eukaryotes requires additional proteins, called transcription factors, to first bind to the promoter region in the DNA template. This binding helps recruit the specific RNAP that can assemble on the DNA and start transcription.
The promoters and enhancers and their accessory proteins allow tight regulation of...
20.9K
Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
7.1K
Suctioning the Nasopharyngeal Airway01:29

Suctioning the Nasopharyngeal Airway

Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
3.3K