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Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy
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Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy

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[Research progress of hepatitis C in 2018]

L Wei1

  • 1Hepatology Department, Peking University People's Hospital, Peking University Hepatology Institute, Beijing 100044, China.

Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology
|January 28, 2019
PubMed

Insights

Direct-acting antiviral agents (DAAs) have made hepatitis C treatment simpler and more accessible globally. Research in 2018 shifted focus to improving treatment accessibility and managing special populations.

Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Major direct-acting antiviral agents (DAAs) are approved, enabling pan-genotypic hepatitis C treatment.
  • Global recommendations favor simple monitoring strategies for hepatitis C.
  • Hepatitis C research in 2018 prioritized treatment accessibility over novel regimens.

Purpose of the Study:

  • To review the current landscape of direct-acting antiviral agents for hepatitis C.
  • To highlight the progress in making hepatitis C treatments more accessible.
  • To identify emerging research areas in hepatitis C management.

Main Methods:

  • Literature review of approved direct-acting antiviral agents.
  • Analysis of research trends in hepatitis C treatment accessibility.
  • Examination of clinical trial progress and regulatory approvals.

Main Results:

  • Pan-genotypic DAAs are globally recommended, simplifying treatment.
  • Increased accessibility and affordability of hepatitis C treatment through collaborative efforts.
  • A growing number of DAAs are approved and in clinical trials, expanding treatment options.
  • Emerging focus on managing hepatitis C in pregnant women, children, and fetuses.

Conclusions:

  • Hepatitis C treatment has significantly advanced with DAAs, improving global outcomes.
  • Efforts to enhance treatment accessibility are yielding positive results.
  • Future research will likely address the management of hepatitis C in vulnerable populations.

Keywords:
Antiviral agentHepatitis C

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