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[Vaccination for meningococcal disease]

Nanna Himmelstrup1, Cecilie Helkjær Engen, Lars Østergaard

  • 1Nanna.himmelstrup@gmail.com.

Ugeskrift for Laeger
|January 29, 2019
PubMed

Insights

Meningitis vaccines protect against invasive meningococcal disease. While effective, immunity wanes, necessitating booster shots for sustained protection against serogroups A, B, C, W135, and Y.

Area of Science:

  • Microbiology
  • Immunology
  • Vaccinology

Background:

  • Neisseria meningitidis causes sepsis and meningitis.
  • Six serogroups (A, B, C, W135, X, Y) cause invasive disease.
  • Denmark offers vaccines against five serogroups.

Purpose of the Study:

  • To review meningococcal vaccines available in Denmark.
  • To assess vaccine efficacy and immunity persistence.
  • To inform recommendations for long-term protection.

Main Methods:

  • Review of marketed vaccines in Denmark.
  • Analysis of vaccine types: conjugated glycoprotein, conjugated, and protein-based.
  • Evaluation of reported efficacy and duration of immunity.

Main Results:

  • Five vaccines target serogroups B, C, and ACWY.
  • Available vaccines include MenC, ACWY-TT/ACWY-CRM, 4CMenB, and MenB-fHbp.
  • Vaccine efficacy is generally good, but immunity wanes over time.

Conclusions:

  • Booster doses are recommended for long-term protection against meningococcal disease.
  • Continued monitoring of vaccine effectiveness and immunity duration is crucial.
  • Vaccination strategies may need adjustments to ensure sustained population immunity.

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