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Updated: Jan 30, 2026
Author Spotlight: Double Posteromedial Approach for Treating Posterior Cruciate Ligament Cysts
Published on: October 20, 2023
[Uncommon mycoses]
Lourdes Viñuela1, Marta Domínguez-Gil1, Mónica de Frutos1
1Servicio de Microbiología y Parasitología, Hospital Universitario Río Hortega, Valladolid, España.
Background:
Fungal infections should be suspected in severe wounds that have been contaminated with organic material or soil, even when the patient is immunocompetent. The aim of this article is to contribute to a better understanding and knowledge of the antifungal sensitivity and epidemiology of some rare pathogens that may trigger severe infections.
Case Report:
Four different moulds were isolated from the wounds of an immunocompetent woman who was involved in a road accident: Lichtheimia corymbifera, Scedosporium boydii, Fusarium solani and Purpureocillium lilacinum. Some of them were isolated from different sites. A profile of in vitro resistance was performed with an Epsilometer (Etest™) using five antifungal agents: voriconazole, posaconazole, itraconazole, anidulafungin an amphotericin B. The results obtained were consistent with those from other cases reported in the literature.
Conclusions:
Early aggressive surgery, antifungal therapy and, above all, frequent debridement of necrotic tissue, are the tools against filamentous fungi infections. Antifungal sensitivity of any mould involved in an infection has to be determined, in order to a better understanding of these rare pathogens whose incidence is increasing.
Insights
This study highlights rare fungal wound infections in an immunocompetent individual. Determining antifungal sensitivity is crucial for treating these emerging infections.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Wound Management
Background:
- Fungal infections can occur in severe wounds contaminated with organic material or soil, even in immunocompetent individuals.
- Rare fungal pathogens can cause severe infections, necessitating a better understanding of their epidemiology and antifungal sensitivity.
Observation:
- Four molds (Lichtheimia corymbifera, Scedosporium boydii, Fusarium solani, Purpureocillium lilacinum) were isolated from an immunocompetent woman's wounds after a road accident.
- In vitro antifungal resistance profiling was performed using Epsilometer (Etest™) with five agents: voriconazole, posaconazole, itraconazole, anidulafungin, and amphotericin B.
Findings:
- The isolated molds exhibited specific in vitro resistance patterns to the tested antifungal agents.
- Results were consistent with previously reported cases in the literature, indicating a potential trend in resistance.
Implications:
- Early aggressive surgical intervention, appropriate antifungal therapy, and frequent debridement of necrotic tissue are essential for managing filamentous fungal infections.
- Determining the antifungal sensitivity of all involved molds is critical for effective treatment and understanding these increasingly prevalent, rare pathogens.
