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The Case for Basic Biological Research.

Isobel Ronai1, Paul E Griffiths2

  • 1Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, Australia; Department of Ecology, Evolution and Environmental Biology, Columbia University, New York City, NY, USA.

Trends in Molecular Medicine
|January 29, 2019
PubMed
Summary
This summary is machine-generated.

Basic biological research is crucial for key molecular biology techniques. However, the current scientific reward system undervalues this foundational research, hindering scientific progress.

Keywords:
CRISPR–Casapplied researchblue skies researchfundamental researchmedicinepure research

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Area of Science:

  • Molecular Biology
  • Basic Biological Research
  • Scientific Research

Background:

  • Biomedical and biological research heavily depend on established molecular biology techniques.
  • The origins and foundational support for these techniques are often overlooked.
  • Understanding the roots of scientific methodologies is essential for continued innovation.

Purpose of the Study:

  • To demonstrate the indispensable role of basic biological research in the development of key molecular biology techniques.
  • To analyze the current scientific reward system's valuation of basic biological research.
  • To highlight the need for re-evaluating research funding and recognition structures.

Main Methods:

  • Historical analysis of the development of eight pivotal molecular biology techniques.
  • Bibliometric analysis to trace the foundational research supporting these techniques.
  • Qualitative assessment of the scientific reward system, including publication and citation metrics.

Main Results:

  • Eight essential molecular biology techniques were found to be direct outcomes of basic biological research.
  • The study identified a significant underappreciation of basic research within the current scientific reward system.
  • Evidence suggests that the system prioritizes applied research over fundamental molecular mechanism studies.

Conclusions:

  • Basic biological research is the bedrock upon which modern molecular biology techniques are built.
  • The scientific reward system fails to adequately recognize and incentivize fundamental research.
  • A shift in valuing basic research is necessary to ensure the sustainability and advancement of biological sciences.