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Principles of Resistance to Targeted Cancer Therapy: Lessons from Basic and Translational Cancer Biology

Amit J Sabnis1, Trever G Bivona2

  • 1Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.

Trends in Molecular Medicine
|January 29, 2019
PubMed

Insights

Cancer therapies targeting genomic drivers are advancing, but therapeutic resistance remains a major challenge. Understanding resistance mechanisms improves targeted treatments and combination therapies for better cancer patient outcomes.

Area of Science:

  • Oncology
  • Genomics
  • Pharmacology

Background:

  • Genomic drivers are key targets for precision cancer medicine.
  • Therapeutic resistance significantly contributes to cancer mortality.
  • Understanding resistance is crucial for improving cancer treatment efficacy.

Purpose of the Study:

  • To review emerging principles of resistance to targeted cancer therapies.
  • To discuss how cancers develop resistance to precision medicine.
  • To highlight advancements in overcoming therapeutic resistance.

Main Methods:

  • Review of current literature on cancer therapeutic resistance.
  • Analysis of mechanisms underlying resistance to targeted therapies.
  • Synthesis of findings from patient samples and laboratory models.

Main Results:

  • Targeted therapies face significant challenges due to cancer's ability to develop resistance.
  • Research into resistance mechanisms has led to improved inhibitors and combination therapies.
  • Deeper understanding of oncogenic mutations and cell survival pathways has been achieved.

Conclusions:

  • Emerging principles of resistance are critical for developing next-generation cancer treatments.
  • Overcoming therapeutic resistance is essential for improving patient survival rates.
  • Continued research into resistance pathways will refine precision oncology strategies.
Keywords:
canceroncogene addictionresistancetyrosine kinase inhibitors

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