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Updated: Jan 30, 2026

Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays
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Redox inhibition of protein phosphatase PP2A: Potential implications in oncogenesis and its progression

Deepika Raman1, Shazib Pervaiz2

  • 1Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Redox Biology
|January 29, 2019
PubMed

Insights

Protein phosphatase 2 (A) (PP2A) is crucial for cell signaling and is a key target in cancer therapy. This review explores PP2A

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Cellular processes rely on protein signaling networks, with protein kinases and phosphatases regulating signal transduction.
  • Protein phosphatase 2A (PP2A) is a major phosphatase, controlling 30-50% of cellular dephosphorylation and regulating key signaling proteins.
  • PP2A's involvement in development and cancer makes it a significant therapeutic target when its activity is dysregulated.

Purpose of the Study:

  • To review the structural and functional complexity of PP2A.
  • To discuss PP2A expression in cancers and its physiological regulation.
  • To highlight recent strategies for PP2A reactivation and the role of cellular redox status in PP2A regulation.

Main Methods:

  • Literature review and synthesis of existing research on PP2A.
  • Analysis of PP2A's role in various signaling pathways.
  • Examination of the impact of cellular redox status on PP2A structure and function.

Main Results:

  • PP2A's intricate structure and function are central to its regulatory roles.
  • PP2A deregulation is implicated in various cancers, necessitating targeted reactivation strategies.
  • Cellular redox status, particularly reactive oxygen species (ROS), significantly impacts PP2A's structure and activity.

Conclusions:

  • Understanding PP2A's complexity and regulation is vital for cancer therapy.
  • Targeted reactivation of PP2A offers a promising therapeutic avenue.
  • The interplay between PP2A and cellular redox status is a critical factor in cancer progression and treatment.
Keywords:
OncogenesisPP2APeroxynitriteROSTumor suppressor

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