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Updated: Jan 30, 2026

Bioluminescent Orthotopic Model of Pancreatic Cancer Progression
Published on: June 28, 2013
[Research progress of super enhancer in cancer]
Zhi Qiang Wu1,2, Ze Yun Mi3
1Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China.
Abstract:
Super enhancers (SEs) are composed of clusters of enhancers in close genomic proximity. They constitute a large family of regulatory elements that specify gene expression patterns and cell identity. SE regions consist of unusually strong enrichment of binding sites for transcriptional factors, cofactors, and enhancers associated with epigenetic modifications. SEs play important roles in regulating the aberrant gene expression in tumor cells. Via SEs, cancer cells activate the expression of various oncogenes, and promote cell proliferation, invasion and migration properties. Hence suppression of SEs activities could inhibit the growth and survival of cancer cells. In this review, we summarize the fundamental principles, functions and regulation of super enhancers and therapeutic potential in targeting SEs in cancer cells, thereby introducing and providing new conceptions for development of antineoplastic drugs.
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