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Hepatoblastoma with Precocious Puberty.

Enono Yhoshu¹, Yasir A Lone¹, Jai K Mahajan¹

¹Department of Pediatric Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Journal of Indian Association of Pediatric Surgeons

|January 29, 2019

Summary

Hepatoblastoma in children can rarely cause precocious puberty due to elevated hormones like beta-human chorionic gonadotropin. Treatment normalized hormone levels and halted puberty progression, improving outcomes for this rare condition.

Keywords:

Hepatoblastoma precocious puberty virilization

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Area of Science:

Pediatric Oncology
Endocrinology
Tumor Biology

Background:

Hepatoblastoma (HB) is a primary childhood liver cancer often associated with elevated alpha-fetoprotein (α-FP).
Elevated beta-human chorionic gonadotropin (β-hCG) is a rare finding in HB, potentially leading to peripheral precocious puberty (PPP).

Observation:

A case of hepatoblastoma presenting with precocious puberty is described.
Hormonal assays revealed elevated α-FP, β-hCG, and testosterone, with suppressed follicle-stimulating and luteinizing hormone levels.

Findings:

Successful treatment involving chemotherapy and surgery led to normalization of α-FP, β-hCG, and testosterone levels.
The signs of virilization ceased to progress following treatment.

Implications:

This case highlights the importance of considering a tumoral source for hormone production in the evaluation of precocious puberty.
Advances in therapy have improved the prognosis for virilizing hepatoblastoma, previously associated with poor outcomes.