Related Experiment Video
Updated: Jan 30, 2026
09:17
Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
22.3K
Young-Onset Dementia with Lewy Bodies
Yosuke Aiba1, Ryuji Sakakibara1, Tsuyoshi Ogata1
1Dementia Support Team, Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan.
Case Reports in Neurology
|January 29, 2019
Summary
Young-onset dementia with Lewy bodies (YOD-DLB) can present with subtle cognitive decline. This case highlights key non-motor and imaging features aiding YOD-DLB diagnosis in challenging cases.
Area of Science:
- Neurology
- Neurodegenerative Diseases
Background:
- Young-onset dementia (<65 years) presents diagnostic challenges.
- Distinguishing between dementia subtypes is crucial for management.
Observation:
- A 61-year-old man presented with executive cognitive impairment.
- Initial suspicion was young-onset Alzheimer's disease.
- He exhibited anosmia, erectile dysfunction, hypersexuality, constipation, REM sleep behavior disorder, and emotional lability.
Findings:
- Brain perfusion SPECT, nigrosome MRI, DAT scan, and MIBG myocardial scintigraphy were positive.
- These findings, alongside non-motor symptoms, confirmed young-onset dementia with Lewy bodies (YOD-DLB).
Implications:
- This case underscores the importance of considering YOD-DLB in patients with early cognitive decline and specific non-motor symptoms.
- Accurate diagnosis facilitates appropriate patient management and care strategies.
- Further prospective studies are needed for optimal YOD-DLB diagnosis and follow-up.
Keywords:
Dementia with Lewy bodiesDopamine transporter scanMIBG myocardial scintigraphyMild cognitive impairmentYoung onsetMore Related Videos
Related Concept Videos
02:33Lewis Acids and Bases
48.3K
In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
48.3K
02:16Lewis Acids and Bases
17.1K
This lesson delves into Lewis acids and bases in the context of the octet rule for electron-deficient compounds. Here, the concept is discussed, emphasizing the group 13 elements like boron or aluminium. Since group 13 elements possess three valence electrons, they form trivalent compounds with a sextet of electrons and a vacant orbital for the central atom. Consequently, these electron-deficient compounds accept electrons from other species to complete their octet in a chemical reaction. They...
17.1K
02:36Lewis Symbols and the Octet Rule
80.6K
Chemical bonds are complex interactions between two or more atoms or ions, which reduce the potential energy of the molecule. Gilbert N. Lewis developed a model called the Lewis model that simplified the depiction of chemical bond formation and provided straightforward explanations for the chemical bonds seen in most common compounds.
80.6K
01:30Dementia
571
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
571
02:46Covalent Bonding and Lewis Structures
61.3K
Compared to ionic bonds, which results from the transfer of electrons between metallic and nonmetallic atoms, covalent bonds result from the mutual attraction of atoms for a “shared” pair of electrons.
61.3K
02:54Lewis Structures of Molecular Compounds and Polyatomic Ions
45.2K
To draw Lewis structures for complicated molecules and molecular ions, it is helpful to follow a step-by-step procedure as outlined:
45.2K