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Mitochondria as a Target for Mitigating Sarcopenia.

Paul M Coen1, Robert V Musci2, J Matthew Hinkley1

  • 1Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, United States.

Frontiers in Physiology
|January 29, 2019
PubMed
Summary
This summary is machine-generated.

Sarcopenia, the age-related loss of muscle, is linked to mitochondrial dysfunction and impaired protein maintenance. Exercise improves these factors, offering a therapeutic approach to combat age-related muscle decline.

Keywords:
agingexercisemitochondriasarcopeniaskeletal muscletreatment

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Area of Science:

  • Gerontology
  • Muscle Biology
  • Cellular Aging

Background:

  • Sarcopenia is the age-related decline in muscle mass, strength, and function.
  • It leads to reduced mobility, independence, and increased comorbidities in older adults.
  • Mitochondrial dysfunction and impaired proteostasis are key contributors to sarcopenia's development.

Purpose of the Study:

  • To review the evidence linking mitochondria and proteostasis to sarcopenia.
  • To discuss the therapeutic potential of interventions targeting these mechanisms.
  • To highlight exercise as a current and potential future treatment strategy.

Main Methods:

  • Literature review of studies on sarcopenia, mitochondria, and proteostasis.
  • Analysis of the role of exercise in mitigating sarcopenia.
  • Discussion of molecular targets for sarcopenia therapies.

Main Results:

  • Mitochondrial dysfunction and impaired proteostatic mechanisms are significant factors in sarcopenia.
  • Exercise effectively treats sarcopenia by enhancing mitochondrial energetics and protein turnover.
  • Exercise interventions can identify new molecular targets for sarcopenia therapies.

Conclusions:

  • Targeting mitochondrial function and proteostatic maintenance holds therapeutic promise for sarcopenia.
  • Exercise is the primary effective intervention, improving key molecular pathways.
  • Further research into these mechanisms can lead to novel sarcopenia treatments.