Related Experiment Video
Updated: Jan 30, 2026

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
Published on: June 7, 2024
Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors
Alexandre Thibault Jacques Maria1,2,3, Léo Partouche1,2, Radjiv Goulabchand1,2
1Medical School, Montpellier University, Montpellier, France.
Abstract:
Systemic sclerosis (SSc) is an autoimmune connective tissue disorder, characterized by multisystem involvement, vasculopathy, and fibrosis. An increased risk of malignancy is observed in SSc (including breast and lung cancers), and in a subgroup of patients with specific autoantibodies (i.e., anti-RNA polymerase III and related autoantibodies), SSc could be a paraneoplastic syndrome and might be directly related to an immune response against cancer. Herein, we reviewed the literature, focusing on the most recent articles, and shed light onto the potential relationship between cancer and scleroderma regarding temporal and immunological dimensions.
Related Concept Videos
Relationship Formation
Ending Relationships
What is the Immune System?
Relationship Growth
Social Relationships and Well-Being
Close Relationships and Culture

