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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
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Blood Coagulation Following an Acute Ischemic Stroke.
M D Sfredel1, E Burada1, B Cătălin1,2
1Department of Physiology, University of Medicine and Pharmacy from Craiova, Romania.
Current Health Sciences Journal
|January 29, 2019
Summary
Optical coherence tomography reveals differences in blood coagulation between stroke patients and healthy individuals. Stroke patients
Area of Science:
- Biomedical Engineering
- Neurology
- Hematology
Background:
- Hemostasis is crucial for stopping bleeding but its role in stroke requires more study.
- Ischemic stroke is a common vascular event.
- Hypercoagulable states may contribute to stroke pathogenesis.
Purpose of the Study:
- To investigate differences in blood coagulation dynamics in acute ischemic stroke patients.
- To explore the potential of optical coherence tomography (OCT) in assessing coagulation.
- To determine if stroke impacts the randomness of the coagulation process.
Main Methods:
- Collected fresh whole blood from 61 acute ischemic stroke patients and 18 healthy controls.
- Utilized optical coherence tomography (OCT) imaging (OCT1300SS system) to analyze blood coagulation.
- Processed OCT images using ImageJ, analyzing gray value metrics (mean, integrated density, skewness, kurtosis).
Main Results:
- Optical coherence tomography detected intrinsic differences in mean gray value and integrated intensity during coagulation.
- Data distribution analysis confirmed these observed differences between patient groups.
- Coagulation in stroke patients exhibited a more symmetrical gray value distribution compared to controls.
Conclusions:
- Normal blood coagulation is not a random process.
- The coagulation process in acute ischemic stroke patients appears more randomized.
- OCT imaging shows potential for differentiating coagulation characteristics in stroke.
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