Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

4.0K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.0K
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups

29.8K

Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.8K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

1.1K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.1K
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

6.7K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
6.7K
Design Example: Calculating Safe Diameter for Wind-Exposed Disc01:17

Design Example: Calculating Safe Diameter for Wind-Exposed Disc

357
Assessing safety in wind-exposed installations is crucial to preventing potential failures. This example explores the calculation and design adjustments needed to mount a circular disc on a building facade, where wind forces are a primary concern. A 4-meter diameter disc was initially designed as an aesthetic feature facing winds at a velocity of 25 meters per second, with an air density of 1.25 kilograms per cubic meter. Given these conditions, the drag force on the disc was determined using...
357
Sample Preparation for Analysis: Advanced Techniques01:08

Sample Preparation for Analysis: Advanced Techniques

1.4K
Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Decade of Leadership and Impact: Celebrating 10 Years of the ORS Spine Section.

JOR spine·2026
Same author

Genome-edited safe and immune-evasive human pluripotent cells: Potential solution for allogeneic therapies.

Stem cell reports·2026
Same author

Advancing Basic and Preclinical Spine Research: Highlights From the ORS PSRS 7th International Spine Research Symposium.

JOR spine·2026
Same author

Tribute to Dr. Frank Beier (1965-2025).

Osteoarthritis and cartilage·2026
Same author

Sex Hormones Attenuate Pro-Inflammatory Gene Expression in Nucleus Pulposus and Annulus Fibrosus Cells in a Cell-Type Specific Manner.

JOR spine·2026
Same author

Tribute to Dr. Frank Beier (1965-2025).

Osteoarthritis and cartilage·2025

Related Experiment Video

Updated: Jan 30, 2026

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
06:22

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Published on: July 8, 2021

2.6K

Latest advances in intervertebral disc development and progenitor cells.

Cheryle A Séguin1, Danny Chan2, Chitra L Dahia3

  • 1Schulich School of Medicine and Dentistry Bone and Joint Institute, The University of Western Ontario London ON Canada.

JOR Spine
|January 29, 2019
PubMed
Summary

This review covers advances in intervertebral disc (IVD) development, focusing on molecular pathways controlling tissue formation. Understanding these mechanisms is key to addressing degeneration during aging, disease, and repair.

Keywords:
developmentstem celltissue‐specific progenitor cells

More Related Videos

An In Vitro Organ Culture Model of the Murine Intervertebral Disc
08:03

An In Vitro Organ Culture Model of the Murine Intervertebral Disc

Published on: April 11, 2017

10.3K
Preparation of Intact Bovine Tail Intervertebral Discs for Organ Culture
13:37

Preparation of Intact Bovine Tail Intervertebral Discs for Organ Culture

Published on: February 2, 2012

15.0K

Related Experiment Videos

Last Updated: Jan 30, 2026

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
06:22

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration

Published on: July 8, 2021

2.6K
An In Vitro Organ Culture Model of the Murine Intervertebral Disc
08:03

An In Vitro Organ Culture Model of the Murine Intervertebral Disc

Published on: April 11, 2017

10.3K
Preparation of Intact Bovine Tail Intervertebral Discs for Organ Culture
13:37

Preparation of Intact Bovine Tail Intervertebral Discs for Organ Culture

Published on: February 2, 2012

15.0K

Area of Science:

  • Biomedical Engineering
  • Developmental Biology
  • Spine Research

Background:

  • Intervertebral disc (IVD) degeneration is a significant health issue.
  • Understanding IVD development is crucial for regenerative strategies.

Purpose of the Study:

  • To review recent advances in IVD development.
  • To highlight molecular pathways governing IVD formation.
  • To explore modifications during aging, disease, and repair.

Main Methods:

  • Review of key topics from the ORS-Philadelphia Spine Research Society Symposium.
  • Emphasis on molecular pathways and cellular mechanisms.
  • Analysis of cell-cell communication, gene regulation, and growth factors.

Main Results:

  • Identification of pivotal molecular pathways in IVD formation.
  • Insights into cellular and molecular changes during aging and disease.
  • Understanding of factors influencing tissue repair.

Conclusions:

  • Comprehending the cellular and molecular basis of IVD degeneration is essential.
  • Dynamic interplay of cellular communication, gene regulation, and growth factors is vital for healthy tissue.
  • This knowledge aids in developing therapeutic strategies for disc disorders.