Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amyloidosis.

C P Maury1

  • 1Fourth Department of Medicine, University of Helsinki, Finland.

Scandinavian Journal of Rheumatology. Supplement
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Recent research clarifies the pathogenesis of AA amyloidosis, focusing on the serum amyloid A (SAA) precursor and its role in amyloid deposition and resolution. This work enhances understanding of amyloid formation and degradation dynamics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fibrillogenesis in gelsolin-related familial amyloidosis.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis·2003
Same author

Apolipoprotein E phenotypes in rheumatoid arthritis with or without amyloidosis.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis·2002
Same author

Is EDRF a specific marker for TSEs?

Nature medicine·2001
Same author

Danish type gelsolin related amyloidosis: 654G-T mutation is associated with a disease pathogenetically and clinically similar to that caused by the 654G-A mutation (familial amyloidosis of the Finnish type).

Journal of clinical pathology·2000
Same author

Identification of the circulating amyloid precursor and other gelsolin metabolites in patients with G654A mutation in the gelsolin gene (Finnish familial amyloidosis): pathogenetic and diagnostic implications.

Laboratory investigation; a journal of technical methods and pathology·1997
Same author

Alzheimer's disease-associated presenilins 1 and 2: accelerated amyloid fibril formation of mutant 410 Cys-->Tyr and 141 Asn-->Ile peptides.

Biochemical and biophysical research communications·1997
Same journal

Abstract of the 35th Scandinavian Congress of Rheumatology, September 20-23, 2014, Stockholm, Sweden.

Scandinavian journal of rheumatology. Supplement·2014
Same journal

Abstracts of the 34th Scandinavian Congress of Rheumatology. Copenhagen, Denmark. September 2-5, 2012.

Scandinavian journal of rheumatology. Supplement·2012
Same journal

How should impaired morning function in rheumatoid arthritis be treated?

Scandinavian journal of rheumatology. Supplement·2011
Same journal

Morning stiffness and other patient-reported outcomes of rheumatoid arthritis in clinical practice.

Scandinavian journal of rheumatology. Supplement·2011
Same journal

How should morning function in rheumatoid arthritis be assessed? Bibliographic study of current assessment.

Scandinavian journal of rheumatology. Supplement·2011
Same journal

How much is a reduction in morning stiffness worth to patients with rheumatoid arthritis?

Scandinavian journal of rheumatology. Supplement·2011
See all related articles

Area of Science:

  • Biochemistry
  • Immunology
  • Pathology

Background:

  • Amyloidosis is a group of diseases characterized by the deposition of amyloid fibrils.
  • AA amyloidosis is associated with chronic inflammation and involves serum amyloid A (SAA) protein.
  • Understanding the pathogenesis of AA amyloidosis is crucial for developing effective treatments.

Purpose of the Study:

  • To provide new insights into the pathogenesis of AA amyloidosis.
  • To broaden the knowledge of amyloid deposition and resolution mechanisms.
  • To clarify the precursor-product relationship between SAA, protein AA, and fibrillar amyloid A.

Main Methods:

  • Extensive studies on the structure, synthesis, and plasma clearance of SAA.
  • Investigation of enzymatic processes involved in SAA cleavage and protein AA degradation.

Related Experiment Videos

  • Exploration of the role of amyloid P component in AA amyloidogenesis.

    • Main Results:

    • Clarified the precursor-product relationship between circulating SAA, protein AA, and fibrillar amyloid A.
    • Accumulated information on enzymatic processes in SAA cleavage and protein AA degradation.
    • Presented a new view on the role of amyloid P component in AA amyloidogenesis.

    Conclusions:

    • The pathogenesis of AA amyloidosis is a dynamic process.
    • Recent studies have significantly advanced the understanding of AA amyloidosis mechanisms.
    • Further research into SAA metabolism and amyloid P component interactions is warranted.