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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
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Polymers, responsiveness and cancer therapy.

Anil M Pethe1, Khushwant S Yadav1

  • 1a Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS (Deemed to be University) , Mumbai , Maharashtra , India.

Artificial Cells, Nanomedicine, and Biotechnology
|January 29, 2019
PubMed
Summary

Stimuli-responsive polymers offer new ways to mimic complex biological processes in cancer therapy. These advanced materials can be designed to respond to multiple triggers, enabling targeted drug delivery and improved treatment outcomes.

Keywords:
Responsivenesscancermicellesnanogelpolymers

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Cancer Therapeutics

Background:

  • Cancer therapy involves complex biological processes with simultaneous changes.
  • Mimicking these processes requires understanding and predicting stimuli-responsive behaviors.
  • Polymers can exhibit simultaneous or sequential responses in biological environments.

Purpose of the Study:

  • To review stimuli-responsive polymers and multi-responsiveness in cancer therapy.
  • To explore the exploitation of various stimuli (temperature, pH, enzymes) in multi-stimuli settings.
  • To discuss the role of nanogels and micelles as responsive polymeric carriers.

Main Methods:

  • Review of existing literature on stimuli-responsive polymers.
  • Analysis of multi-stimuli responsive systems for cancer treatment.
  • Discussion of nanogels and micelles as drug delivery vehicles.

Main Results:

  • Multi-stimuli responsive systems are significant due to the complex tumor microenvironment.
  • Responsive materials can mimic biological processes at the molecular level.
  • Custom-designed molecules can be developed for targeted cancer cell manipulation.

Conclusions:

  • Stimuli-responsive polymers are crucial for mimicking complex biological events in cancer therapy.
  • Multi-stimuli responsive systems offer enhanced capabilities for targeted drug delivery.
  • These advanced materials hold promise for developing next-generation cancer treatments.