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Updated: Jan 30, 2026
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Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets
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Radiation-induced brachial plexus neuropathy: A review
Anshu C Warade1, Ashish K Jha1, Sanjeev Pattankar1
1Department of Neurosurgery, P. D. Hinduja Hospital, Mumbai, Maharashtra, India.
Neurology India
|January 29, 2019
Summary
Radiation-induced brachial plexus neuropathy (RIBPN) is a rare complication of cancer radiation therapy. Early diagnosis and surgical intervention are key for managing this condition, which causes severe pain and limb dysfunction.
Area of Science:
- Neurology
- Oncology
- Radiotherapy
Background:
- Radiation-induced brachial plexus neuropathy (RIBPN) is an uncommon, delayed, nontraumatic neuropathy.
- It frequently follows radiation for neck, axilla, and chest wall carcinomas, especially breast cancer.
- Improved cancer survival rates have increased RIBPN incidence.
Purpose of the Study:
- To review the clinical experience in managing RIBPN.
- To highlight features of 11 patients diagnosed with RIBPN between 2004 and 2017.
- To discuss clinical findings, natural history, pathophysiology, radiological characteristics, and management.
Main Methods:
- Retrospective review of 11 patients with RIBPN managed between 2004 and 2017.
- Analysis of clinical findings, natural history, and diagnostic characteristics.
- Evaluation of treatment outcomes for surgical intervention.
Main Results:
- RIBPN presents with severe neurogenic pain and progressive sensory-motor deficits in the upper limb.
- Diagnosis is often challenging due to confusion with tumor recurrence.
- External neurolysis with scar excision is a recommended management for severe cases.
Conclusions:
- RIBPN is an increasingly recognized complication of cancer radiotherapy.
- Timely diagnosis and surgical management are crucial for improving patient outcomes.
- Further research into pathophysiology and treatment is warranted.
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