Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mismatch Repair01:36

Mismatch Repair

43.7K
Overview
43.7K
Mismatch Repair01:20

Mismatch Repair

6.5K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
6.5K
Overview of DNA Repair02:25

Overview of DNA Repair

33.6K
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
33.6K
Base Excision Repair01:54

Base Excision Repair

26.3K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.3K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

40.8K
Overview
40.8K
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

8.0K
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HSR26-232: Disparities in ICU Utilization and Mortality in Tumor Lysis Syndrome: Evaluating Equity in Supportive Care Per NCCN Guidelines.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

HSR26-265: Adherence to NCCN Guidelines for Psychosocial Distress Management: Impact of Psychiatric Comorbidities on Inpatient Outcomes in Metastatic Cancer.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

HSR26-265: Adherence to NCCN Guidelines for Psychosocial Distress Management: Impact of Psychiatric Comorbidities on Inpatient Outcomes in Metastatic Cancer.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

HSR26-232: Disparities in ICU Utilization and Mortality in Tumor Lysis Syndrome: Evaluating Equity in Supportive Care Per NCCN Guidelines.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Core outcomes in nerve surgery: development of a core outcome set for lateral femoral cutaneous neuropathy.

Journal of neurosurgery·2026
Same author

Prophylaxis for venous thromboembolism in traumatic brain injury: protocol for a randomised controlled trial.

BMJ open·2025

Related Experiment Video

Updated: Jan 30, 2026

Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro
08:16

Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro

Published on: May 20, 2020

7.9K

Recent advances in nerve repair.

Sudheesh Ramachandran1, Rajiv Midha2

  • 1Department of Neurosurgery, Division of Spine Surgery, Clinical Neurosciences Centre, University of Utah, Salt Lake City, Utah, USA.

Neurology India
|January 29, 2019
PubMed
Summary
This summary is machine-generated.

Peripheral nerve injuries require complex management. Nerve transfers are increasingly used, offering excellent functional outcomes due to advances in understanding brain plasticity and rehabilitation.

Keywords:
Nerve injurynerve graftsnerve transfersoutcomessurgical techniques

More Related Videos

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
20:14

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

16.8K
The Fibular Nerve Injury Method: A Reliable Assay to Identify and Test Factors That Repair Neuromuscular Junctions
06:01

The Fibular Nerve Injury Method: A Reliable Assay to Identify and Test Factors That Repair Neuromuscular Junctions

Published on: August 11, 2016

16.6K

Related Experiment Videos

Last Updated: Jan 30, 2026

Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro
08:16

Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro

Published on: May 20, 2020

7.9K
Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
20:14

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

16.8K
The Fibular Nerve Injury Method: A Reliable Assay to Identify and Test Factors That Repair Neuromuscular Junctions
06:01

The Fibular Nerve Injury Method: A Reliable Assay to Identify and Test Factors That Repair Neuromuscular Junctions

Published on: August 11, 2016

16.6K

Area of Science:

  • Neurosurgery
  • Regenerative Medicine
  • Orthopedics

Background:

  • Peripheral nerve injuries (PNIs) present significant clinical challenges.
  • Microsurgical repair, including grafts and tubes, is a primary treatment.
  • Nerve transfers are gaining prominence for PNI management.

Purpose of the Study:

  • To review current strategies for peripheral nerve repair.
  • To emphasize existing nerve transfer techniques and their outcomes.
  • To discuss the advancements contributing to the success of nerve transfers.

Main Methods:

  • Review of current literature on peripheral nerve repair strategies.
  • Analysis of outcomes associated with various nerve repair techniques.
  • Special focus on the methodologies and application of nerve transfers.

Main Results:

  • Nerve transfers are demonstrating excellent functional outcomes in PNI management.
  • Increased understanding of cortical plasticity, motor re-education, and rehabilitation supports nerve transfer efficacy.
  • Current strategies encompass direct repair, grafts, tubes, and transfers, each with specific indications.

Conclusions:

  • Nerve transfers represent a highly effective approach for managing peripheral nerve injuries.
  • Continued research and understanding of neuroplasticity will further refine nerve transfer techniques.
  • Optimized perioperative rehabilitation is crucial for maximizing functional recovery after nerve repair.