[The study of activity of matrix metalloproteinases abd reactants of inflammation in patients with endocarditis.]

The purpose of study is to establish and compare concentration of acute-phase indices, total activity of matrix metalloproteinases-2, -7 (MMP-2, MMP-7) of blood serum in patients with vegetations on heart valvular apparatus of infectious and noninfectious nature; to apply a correlation analysis between these indices; to evaluate advantages of technique of detection of total activity of MMP-2 and MMP-7 in patients with endocarditis of various etiology. The sampling consisted of 175 examined patients separated on two groups. The first group included 81 patients with noninfectious endocarditis; the second group included 94 patients with infectious endocarditis. The activity of MMP-2 and MMP-7 was detected using fluorescent substrate, specific to MMP-2 and MMP-7. The significant increasing of activity of MMP-2 and MMP-7 in blood serum of patients with vegetation syndrome as compared with activity of enzymes in blood of healthy individuals (control group). In the group with noninfectious endocarditis activity of MMP-2 and MMP-7 made up to 84,10 ± 12,37; in the group with infectious endocarditis - 227,30 ± 44,70; in the control group - 4,16 ± 2,28 mkmol/MCA/l per hour (р < 0,05). No reliable difference between endocarditis of various nature was established. The correlation was observed between activity of matrix metalloproteinases and reactants of acute phase of inflammation.