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Updated: Jan 30, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Postural Control Complexity and Fatigue in Minimally Affected Individuals with Multiple Sclerosis
Felipe B Santinelli1, Fabio A Barbieri1, Carina F Pinheiro2
1a Human Movement Research Laboratory (MOVI-LAB), Department of Physical Education, Graduate Program in Movement Sciences , São Paulo State University (UNESP)-Campus Bauru , Brazil .
Abstract:
This study investigated changes in postural control complexity in people with multiple sclerosis (PwMS) before and after a fatigue protocol. Thirteen minimally affected PwMS (1.53 ± 1.03- Expanded Disability Status Scale) and 12 non-MS controls. Postural test included quiet stance on a force platform under two visual conditions (saccades and fixation) before and after a fatigue protocol. Postural complexity was assessed through the multiscale entropy. A three-way ANOVA showed a main effect of fatigue in the medial-lateral direction (p <0.007), with fatigue protocol reducing postural complexity in both groups. No differences were found between groups or visual conditions. Minimally affected PwMS demonstrated similar postural complexity compared with non-MS controls under both visual tasks and showed similar decrements in postural complexity as a result of fatigue.
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