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Antimicrobial treatment of Kocuria kristinae invasive infections: Systematic review

Radica S Živković Zarić1, Ana V Pejčić1, Slobodan M Janković1

  • 1a Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia.

Journal of Chemotherapy (Florence, Italy)
|January 29, 2019
PubMed

Insights

Kocuria kristinae can cause invasive infections in various human tissues, often isolated from blood. Antibiotic treatment is generally effective, with vancomycin recommended for initial therapy.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases

Background:

  • Kocuria kristinae is increasingly recognized as a potential human pathogen.
  • Invasive infections caused by K. kristinae can affect patients of all ages.

Purpose of the Study:

  • To systematically review invasive infections caused by Kocuria kristinae in humans.
  • To evaluate the outcomes of antibiotic treatment for K. kristinae infections.

Main Methods:

  • Systematic literature search of multiple databases (MEDLINE, EBSCO, SCOPUS, SCINDEKS, Google Scholar).
  • Inclusion of primary case reports and case series describing invasive K. kristinae infections.

Main Results:

  • K. kristinae was isolated from various body sites, most commonly blood, but also peritoneal fluid, pus, sputum, and others.
  • Antibiotic treatment demonstrated high efficacy, with only one reported death.
  • Highest susceptibility observed for vancomycin, linezolid, rifampicin, teicoplanin, tigecycline, cefotaxime, ampicillin/sulbactam, minocycline, and meropenem.

Conclusions:

  • Kocuria kristinae is a versatile pathogen capable of causing diverse invasive infections.
  • Parenteral vancomycin combined with another susceptible antibiotic is recommended for initial Kocuria kristinae infection treatment.
Keywords:
Antibiotic treatmentInvasive infectionsKocuria kristinaeSystematic review

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