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Related Experiment Video

Updated: Jan 30, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Ovarian stimulation for preimplantation genetic testing.

Jorge Rodriguez-Purata1, Francisca Martinez1

  • 1Hospital Universitario Dexeus, Barcelona, Spain.

Reproduction (Cambridge, England)
|January 29, 2019
PubMed
Summary

Optimizing controlled ovarian stimulation for preimplantation genetic testing aims to maximize euploid embryos for transfer. This review covers strategies to increase oocyte yield while preventing complications like OHSS.

Area of Science:

  • Reproductive Endocrinology
  • In Vitro Fertilization
  • Genetics

Background:

  • Controlled ovarian stimulation (COS) is crucial for in vitro fertilization (IVF) cycles.
  • Preimplantation genetic testing (PGT) requires sufficient embryos for accurate diagnosis.
  • The goal of COS has evolved to maximize euploid embryo yield for PGT.

Purpose of the Study:

  • To provide a narrative review of management strategies for COS in patients undergoing PGT.
  • To summarize treatment variables and stimulation strategies to optimize outcomes.

Main Methods:

  • Electronic literature search for studies on ovarian stimulation and PGT until December 2017.
  • Classification of studies by design: RCTs, prospective trials, retrospective studies, and experimental studies.

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Main Results:

  • Key variables influencing COS for PGT include oocyte yield, oral contraceptive use, stimulation protocols, gonadotropin choice, and trigger methods.
  • Strategies like mild or random-start stimulation, novel progesterone protocols, and agonist/dual triggers are discussed.
  • Emphasis on oocyte/embryo accumulation and optimal intervals between stimulation cycles.

Conclusions:

  • The primary objective of COS in PGT is to obtain a maximum number of embryos for biopsy, increasing the chance of a euploid embryo for transfer.
  • Vitrification and deferred embryo transfer mitigate risks of OHSS and suboptimal endometrial receptivity.
  • Review addresses practical clinical questions regarding COS management for PGT success.