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Suicidal behavior, impulsiveness and serotonin.

A Roy1, M Linnoila

  • 1Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.

Acta Psychiatrica Scandinavica
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

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Abnormal serotonin systems are linked to suicide attempts and aggression, potentially due to impaired impulse control. Further research into biological markers for these behaviors is needed.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Science

Background:

  • Accumulating evidence suggests a link between serotonin system abnormalities and suicidal behavior.
  • Aggression towards others and objects may also be associated with altered serotonin pathways.
  • Poor impulse control is a common feature in these behaviors and may relate to serotonin turnover.

Purpose of the Study:

  • To review evidence connecting serotonin system dysfunction to suicidal and aggressive behaviors.
  • To explore the role of central serotonin turnover in impulse control deficits.
  • To highlight the need for research into peripheral biological markers for suicidal and impulsive actions.

Main Methods:

  • Review of preclinical studies.
  • Analysis of clinical data.

Related Experiment Videos

  • Examination of postmortem findings.

    • Main Results:

    • Evidence suggests a correlation between serotonin system abnormalities and both suicide attempts and aggression.
    • Low central serotonin turnover is implicated as a potential neurobiological basis for poor impulse control.
    • The reviewed studies underscore the complexity and multifactorial nature of these behaviors.

    Conclusions:

    • Serotonin system dysfunction is a significant factor associated with suicidal and aggressive behaviors.
    • Further investigation into peripheral biological markers is crucial for understanding and potentially predicting these behaviors.
    • Understanding the neurobiology of impulse control is key to addressing aggression and suicidality.