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Updated: Jan 30, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Hemorrhagic conversion after alteplase administration in a patient with vasculitis and acute ischemic stroke
Brian W Gilbert1, Laxmi Dhakal2, Alison Lacy2
1Department of Pharmacy, Wesley Medical Center, Wichita, KS.
Purpose:
A case of alteplase administration to a patient with vasculitis and acute ischemic stroke (AIS) is reported.
Summary:
A 38-year-old woman with a recent diagnosis of granulomatosis with polyangiitis (GPA) received alteplase for AIS and developed symptomatic hemorrhagic conversion. Published reports regarding the safety of thrombolytic therapy in patients with a high inflammatory burden are inconsistent. The current case adds to the literature on the topic.
Conclusion:
More data regarding alteplase treatment in patients with GPA are needed to further establish the safety of this therapy.
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