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The Macrophage 'Do not eat me' signal, CD47, is a clinically validated cancer immunotherapy target

C H Takimoto1, M P Chao1, C Gibbs1

  • 1Forty Seven, Inc, Menlo Park.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|January 29, 2019
PubMed
Abstract

No abstract available in PubMed .

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized by phagocytes.