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Updated: Jan 30, 2026
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Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
9.5K
A practical guide for pharmacists to successfully implement penicillin allergy skin testing.
Christopher M Bland1, P Brandon Bookstaver2, Nicole C Griffith3
1University of Georgia College of Pharmacy, Savannah, GA.
Summary
Penicillin allergy skin testing (PAST) confirms true allergies, reducing unnecessary antibiotic use. Pharmacists can lead PAST implementation to improve patient outcomes and combat antimicrobial resistance.
Area of Science:
- Pharmacology
- Infectious Diseases
- Clinical Pharmacy
Background:
- Penicillin allergy labels lead to broad-spectrum antibiotic use, increasing resistance, costs, and adverse outcomes.
- Less than 10% of patients with a penicillin allergy label are confirmed via skin testing.
- Antimicrobial stewardship programs recommend penicillin allergy skin testing (PAST) to optimize antibiotic selection.
Purpose of the Study:
- To provide practical guidance for pharmacists on implementing penicillin allergy skin testing (PAST).
- To support pharmacists in leading PAST initiatives within healthcare settings.
Main Methods:
- Review of existing models for successful PAST implementation.
- Consideration of logistical factors including target population, preparation, leadership, resources, and regulations.
Main Results:
- Successful PAST implementation models exist across various healthcare facilities.
- Pharmacists are well-positioned as leaders in drug allergy management and antimicrobial stewardship.
- PAST has demonstrated beneficial effects in improving patient outcomes when integrated into stewardship programs.
Conclusions:
- Penicillin allergy skin testing (PAST) is an effective antimicrobial stewardship tool for optimizing prescribing.
- Pharmacists play a crucial role in providing PAST services in inpatient and outpatient settings.
- Implementing PAST enhances the use of first-line antibiotics, leading to better clinical outcomes.
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