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Culture of Bladder Cancer Organoids as Precision Medicine Tools
Published on: December 28, 2021
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Lectins as possible tools for improved urinary bladder cancer management.
Tanja Višnjar1, Rok Romih1, Daša Zupančič1
1Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana, Slovenia.
Glycobiology
|January 29, 2019
Summary
Altered carbohydrate structures on bladder cancer cells offer new diagnostic and therapeutic targets. Lectins, proteins that bind carbohydrates, show potential for detecting and treating urothelial carcinoma, though clinical applications are pending.
Area of Science:
- Biochemistry
- Oncology
- Biotechnology
Background:
- Urinary bladder cancer is a prevalent malignancy with challenging diagnosis and limited treatment options.
- Urothelial cells form a crucial barrier, and their surface carbohydrate composition changes during cancer development.
- These alterations present a promising avenue for bladder cancer diagnosis, therapy, and management.
Purpose of the Study:
- To review current bladder cancer management strategies.
- To explore the utility of lectin-based assays for detecting urothelial carcinoma subtypes.
- To discuss lectin-based approaches for novel bladder cancer treatments and nanotheranostics.
Main Methods:
- Literature review of current bladder cancer management.
- Analysis of research on lectin applications in cancer detection.
- Examination of lectin-based therapeutic strategies and nanotheranostics.
Main Results:
- Carbohydrate changes on urothelial cells are hallmarks of bladder cancer.
- Lectins can detect these subtle carbohydrate alterations.
- Existing lectin research is extensive but yields contradictory results, with no clinical trials to date.
Conclusions:
- Lectins hold significant promise for diagnosing and treating bladder cancer.
- Further research is needed to overcome inconsistencies and translate lectin applications into clinical practice.
- Nanotheranostics offer a path toward personalized bladder cancer management using lectins.
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