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Biophysical analysis of interaction between curcumin and alpha-2-macroglobulin

Syed Saqib Ali1, Mohammad Khalid Zia1, Tooba Siddiqui1

  • 1Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India.

International Journal of Biological Macromolecules
|January 29, 2019
PubMed
Summary

Curcumin binding to alpha-2-macroglobulin (α2M) alters protein structure and reduces its antiproteinase activity. This interaction is spontaneous and exothermic, impacting the protein's overall function.

Keywords:
Alpha-2-macroglobulinAntiproteinase activityCircular dichroismCurcuminFourier transform infrared spectroscopy

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