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In vitro fertilization and autoimmunity: Evidence from an observational study.

R Di Rosa1, S Ferrero2, N Cifani1

  • 1"Sapienza", Università di Roma, Dipartimento di Medicina Clinica e Molecolare, Facoltà di Medicina e Psicologia, Ospedale Sant'Andrea, Via Grottarossa 1035-1039, 00189, Roma, Italy.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|January 29, 2019
PubMed
Summary
This summary is machine-generated.

Antiphospholipid antibodies (aPLs) were found in 8.27% of infertile women undergoing IVF. Evaluating aPLs in these patients can identify those at higher risk for pregnancy complications and miscarriage.

Keywords:
Antiphospholipid antibodiesAntiphospholipid antibody syndromeInfertilityPregnancySystemic autoimmune diseases

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Area of Science:

  • Reproductive Immunology
  • Autoimmunity
  • Infertility Research

Background:

  • Antiphospholipid antibodies (aPLs) are associated with adverse pregnancy outcomes.
  • Infertility affects a significant number of women, and the role of autoimmunity is increasingly recognized.

Purpose of the Study:

  • To determine the prevalence of antiphospholipid antibodies (aPLs) in infertile women undergoing in vitro fertilization (IVF).
  • To identify potential links between aPLs and underlying systemic autoimmune conditions in this patient group.

Main Methods:

  • A retrospective analysis of 520 infertile women undergoing IVF between January 2012 and December 2017.
  • Selection of 100 patient records with positive autoantibodies for detailed evaluation.

Main Results:

  • 19.23% of women had positive autoantibodies; 6.73% met criteria for a systemic disease.
  • Antiphospholipid antibodies (aPLs) were detected in 8.27% of women (43/520).
  • Lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) were the most common aPLs.

Conclusions:

  • Infertile women may represent a subgroup of patients with undiagnosed systemic autoimmune syndromes.
  • Routine evaluation of aPLs in women undergoing IVF is recommended to identify those at increased risk of miscarriage or pregnancy morbidity.