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Updated: Jan 30, 2026

Culture of myeloid dendritic cells from bone marrow precursors
Published on: July 25, 2008
Precursor B-cell development in bone marrow of Good syndrome patients
Lucía Del Pino Molina1, Marjolein Wentink2, Marcel van Deuren3
1Dept. of Clinical Immunology, La Paz University Hospital, Lymphocyte Pathophysiology in Immunodeficiencies Group La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
Abstract:
Good syndrome is an immunodeficiency presenting with thymoma, hypogammaglobulinemia and almost absent B cells. To investigate the origin of the B-cell lymphopenia in these patients, we studied B cell differentiation in the bone marrow of Good syndrome patients. We found very low numbers of precursor B cells in bone marrow of Good syndrome patients and a differentiation arrest after the pro-B-cell stage; this is different from other agammaglobulinemia patients with a defect in pre B-cell receptor signaling.
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