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Updated: Jan 30, 2026
04:38
Assessment of Sexual Behavior of Male Mice
Published on: March 5, 2020
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Adverse drug reactions on sexual functioning: a systematic overview.
Rineke Gordijn1, Martina Teichert1, Melianthe P J Nicolai2
1Leiden University Medical Center, Department of Clinical Pharmacy & Toxicology, Leiden, The Netherlands.
Drug Discovery Today
|January 29, 2019
Summary
Adverse drug reactions affecting sexual function are common, impacting quality of life and medication adherence. This review highlights prevalent drugs with sexual side effects, urging clinical consideration for better patient outcomes.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Drug Safety
Background:
- Adverse drug reactions (ADRs) impacting sexual functioning can significantly reduce patient quality of life and adherence to medication.
- A comprehensive overview of drugs associated with sexual ADRs is lacking, potentially indicating knowledge gaps among healthcare professionals.
Purpose of the Study:
- To systematically identify and review drugs registered with at least one sexual ADR.
- To provide an overview of the prevalence and incidence rates of sexual ADRs across different drug classes.
Main Methods:
- Systematic review of Summary of Products Characteristics (SmPCs) for registered drugs.
- Identification of drugs listing sexual dysfunction as an ADR.
Main Results:
- A total of 346 drugs were identified with at least one sexual ADR.
- The 'nervous system' drug class (N) was most frequent (105 drugs), followed by the 'cardiovascular system' (C) (89 drugs).
- Incidence rates for sexual ADRs exceeded 10% for 16 drugs and 1% for 98 drugs.
Conclusions:
- Sexual ADRs are associated with a substantial number of drugs, including frequently prescribed medications.
- Awareness and consideration of sexual ADRs are crucial in clinical practice for optimizing drug therapy and patient well-being.
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