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Updated: Jan 30, 2026
09:41
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
9.1K
New Drugs in Multiple Myeloma
Chutima Kunacheewa1,2, Robert Z Orlowski1,3
1Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA;
Annual Review of Medicine
|January 30, 2019
Summary
Multiple myeloma, a relapsing plasma cell cancer, presents a growing global health challenge. Advances in therapies, including new agents and cellular treatments, offer hope for improved patient outcomes and a potential cure.
Area of Science:
- Hematology
- Oncology
- Pharmacology
Background:
- Multiple myeloma incidence and prevalence are increasing globally, posing a significant healthcare challenge.
- The disease is characterized by a relapsing course, necessitating continuous therapeutic innovation.
- Current treatments include alkylating agents, corticosteroids, and newer classes like monoclonal antibodies and proteasome inhibitors.
Purpose of the Study:
- To review the current therapeutic landscape for multiple myeloma.
- To highlight recent advancements in treatment strategies.
- To discuss the future directions in multiple myeloma drug development.
Main Methods:
- Review of recent basic, translational, and clinical studies.
- Analysis of the existing and emerging therapeutic armamentarium for multiple myeloma.
- Synthesis of data on novel drug classes and cellular therapies.
Main Results:
- The therapeutic options for multiple myeloma have significantly expanded.
- Established treatments include alkylating agents, corticosteroids, deacetylase inhibitors, immunomodulatory agents, monoclonal antibodies, and proteasome inhibitors.
- Numerous novel agents, including small molecules, large molecules, and cellular therapies, are under active development.
Conclusions:
- The expanding therapeutic options offer improved management for multiple myeloma patients.
- Ongoing research and development promise further advancements, potentially leading to a cure.
- The evolving treatment landscape underscores the dynamic nature of multiple myeloma research and patient care.
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